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Gastric cancer is one of the most common tumors. It 5-year survival rate is low, mainly because of a late diagnosis. Endoscopy with gastric biopsies is suggested as the best and most effective diagnostic method for screening of gastric cancer. Because endoscopic screening is an invasive procedure and its higher inspection costs, technical requirements and poor patient compliance, it is difficult for a large-scale screening and early diagnosis of gastric cancer. Serology could be used as a non-invasive screening method for the detection of gastric cancer due to its convenience, relatively low cost, safety, high sensitivity and specificity. In this paper, micro RNA, long noncoding RNA, DNA methylation, circulating tumor cells, pepsinogen, gastrin and other serum markers are reviewed in the early diagnosis of gastric cancer.
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Objective: To discuss application values of serum procalcitonin [PCT], C-reactive protein [CRP] and white blood cells [WBC] count in early diagnosis and treatment of neonatal bacterial infectious diseases
Methods: Clinical data of one hundred and thirty-six newborns with infectious diseases who were admitted into the hospital were retrospectively analyzed. They were divided into bacterial infection group [N=70] and non-bacterial infection group [N=66]. Additionally, sixty-six healthy newborns who underwent physical examination in our hospital in the same period were selected as controls. Subjects in the three groups were all detected for serum PCT, CRP and WBC levels
Results: The levels of PCT, CRP and WBC in the bacterial infection group were much higher than those of the non-bacterial infection group and the healthy control group, and the differences had statistical significance [P<0.05]. The positive rates of PCT, CRP and WBC of the bacterial infection group were higher than those of the non-bacterial infection group [P<0.05]; the specificity and sensitivity of the PCT level were obviously higher than those of the CRP and WBC levels in diagnosing bacterial infectious diseases [P<0.05]
Conclusion: Serum PCR, CRP and WBC levels are of high diagnostic values to neonatal infectious diseases. Compared to WBC and CRP, PCT is more sensitive index in the diagnosis of neonatal infectious diseases
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Objective To investigate the correlations of the levels of serum total cholesterol (TC),high density lipoprotein(HDL),and low density lipoprotein (LDL) with tumor node metastasis (TNM) staging and Lauren's classification in gastric cancer.Methods The blood lipid levels of 157 cases of gastric cancers,80 cases of benign gastric diseases,and 80 cases of normal subjects were detected by the Hitachi 7170A automatic biochemical instrument,and these values were statistically compared with SPSS 19.0.Results The contents of serum TC,HDL,and LDL in the group of gastric cancers were lower than those in the groups of normal subjects and benign gastric diseases (P ＜ 0.05).The contents of serum HDL levels were decreased with the increase of the TNM stage in patients with gastric cancer,and were all lower than the benign gastric diseases and the health control group (P ＜ 0.05).No statistically significant correlation was found in the levels of serum TC,HDL,and LDL in Lauren's histological types of gastric cancers (P ＜0.05).Conclusions Abnormal lipid metabolism had already appeared in gastric cancer,and the decreased serum HDL levels was correlated with TNM stage of gastric cancer.Detection of the changes of lipid levels in patients might be beneficial to the screening and prognosis of gastric cancer.
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Objective To study the distribution and significance of free organophosphorus poisons (FOP)with different degrees of hudrosolubility in the blood and adipose tissues of poisoned rabbits.Methods Seventy two male livid blue rabbits with 2-2.5 kg body weight were divided into 3 groups as per the rabbits intoxicated with different kinds of organophosphorous given subcutaneously,namely monocrotophos(11.12 mg/kg)group,trichloffon(556.0 mg/kg)group and methyl parathion(37.05 mg/kg)group(n =24 in each).Each group was further divided into 4 subgroups(n =6,in each).Blood samples and adipose tissues were collected 1 h,6 h,24 h and 96 h after administration of organophosphorous.Blood cells and plasma were separated.Well-formed adipose tissue homogenates were made.Acetylcholinesterase(AChE)activities were assayed with dithiobisnitrobenzoic acid(DTNB)enzyme kinetic method.The levels of FOPs in blood plasma,blood cells and adipose tissues were determined with enzyme inhibition method.Results There were signiflc.ant differences in FOP concentrations of plasma,blood cells and adipose tissues among moncrotophos group,trichlorfon group and methyl pararthion group at the intervals of 1,6 and 24 hours after organophosphorous administered(all P ＜ 0.05).There were no significant differences in FOP concentrations of moncrotophos among blood plasma,blood cells and adipose tissues at intervals of 1,6,24 and 96 hours.FOP concentrations of trichlorfon in adipose tissues were significantly higher than those in blood cells and plasma at intervals of 1,6,24 hours after organophosphorous administered(P ＜ 0.05).There were significant differences in FOP concentrations of pararthion in blood plasma compared with blood cells and adipose tissues at intervals of 1 and 6 hours after organophosphorous administered(P ＜ 0.05)and no difference was found over 24 hours after administration of organophosphorous(P ＞ 0.05).The significant differences in the rates of FOP clearance from blood and adipose tissues were also found between different organophosphates(P ＜ 0.05,moncrotophos ＞ trichlorfon ＞methyl pararthion).Conclusions With the decrease in hydrosolubility of organophosphates,the increase in adipose tissue-specific retention was found and the time required for clearance from blood and adipose tissue was prolonged.Adipose tissue was the major storage site for organophosphates with low hydrosolubility.
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0.05). Conclusion H pylori infection is closely related with non-cardiac gastric cancer. There is no relationship between H pylori infection and cancerous ulcer. Chronic gastritis, especially H pylori positive one, is the primary disease for developing intestinal-type and diffuse-type carcinoma, and H pylori may be an important initiating factor.